Triazenes: Chemical, Biological, and Clinical Aspects


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Skickas inom vardagar. Laddas ned direkt. More than 25 years have elapsed since the development of the seminal idea which led to the synthesis of dimethyl triazenes as antitumor agents. The original suggestion of Shealy et ale was to use 4-imidazone-carboxarnide as the carrier of a nitro- gen-containing cytotoxic function.

Its lack of antitumor action was attributed to its polarity and to the resulting poor uptake of this hydrophilic chemical.

Triazenes - Chemical, Biological, and Clinical Aspects | Tullio Giraldi | Springer

Preliminary tests showed that DTIC had good antiumor activity in experimental systems. Further tests demonstrated a broad spectrum of action against rodent tumors, and clinical trials indicated activity against human malignancies. Subsequent clinical use of DTIC has demonstrated its usefulness against malignant melanoma, for which it is currently the drug of choice, and its effective- ness in combination chemotherapy in the treatment of other human cancers.

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Because of its antitumor activity the mechan- ism of action of DTIC has been investigated in some detail. The original rationale for its development, that is, the hydrolysis in vivo to diazo-IC, has been shown not to be in- volved in th-e-mechansims of action.

Clinical Management of Chemical and Biological Events (CMCBE) - J. Doucet, MD

DTIC requires metabolic acti- vation before it exerts its biological effects. Passar bra ihop. Unhappiness, Sadness and 'Depression' Tullio Giraldi. Connors , Giuseppe Cartei.

ISBN 13: 9780306436673

A class of antitumor agents is discussed in 16 papers, which include explorations of the synthesis, chemical properties, biotransformation, and pharmacokinetics in animals and humans, and studies of analogous agents and substances affecting the mechanism of triazenes. Specific topics include antimetastatic action, immune responses, xenogenization, clinical use, and therapeutic considerations. Annotation c Book News, Inc.


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Mechanisms of the Biological Actions of Triazenes. Antitumour Action. Hickman L leukaemia Lassiani leukaemia levels Lewis lung carcinoma liver lymphocytes lymphoma M.

Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects Triazenes: Chemical, Biological, and Clinical Aspects
Triazenes: Chemical, Biological, and Clinical Aspects

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